Hormone Therapy for Prostate Cancer Linked With Depression

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Source:   —  April 13, 2016, at 10:10 PM

S. study suggests. Prostate cancer cells necessity testosterone to grow and spread. Researchers focused on a common treatment known as androgen deprivation therapy (ADT), which works by depriving tumor cells of testosterone.

Men who get hormone therapy for prostate cancer may have a higher risk of depression than patients who get different treatment, a U. S. study suggests.

Prostate cancer cells necessity testosterone to grow and spread. Researchers focused on a common treatment known as androgen deprivation therapy (ADT), which works by depriving tumor cells of testosterone. Side effects can comprise sexual dysfunction, wt gain and fatigue.

Patients with prostate cancer who received hormone therapy were twenty-three % more likely to expand depression and twenty-nine % more likely to have inpatient psychiatric treatment than men who received alternative treatments, the study found.

"The take-home message is that the list of potential side effects of hormone therapy is continuing to grow," said senior study author Dr. Paul Nguyen of Brigham and Women'south Hospital and Harvard Medical School in Boston.

"Any man with prostate cancer considering hormone therapy should discover out from their Dr precisely how large the benefit is expected to be in their specific situation so they can weigh it against the list of possible side effects," Nguyen added by email.

To examine the link between hormone therapy and depression, Nguyen and colleagues examined data on more than 78.000 men age sixty-six and older who were treated for prostate cancer from one thousand nine hundred ninety-two to two thousand six.

They followed men for three years, and excluded patients with psychiatric diagnoses in the year before they were diagnosed with tumors.

Nearly 45.000 men in the study received hormone therapy, and they tended to have more advanced disease. They were about seventy-six years elderly on average, about two years older than the typical age of the men who received different treatments.

From six months to three years after diagnosis, 7.1 % of the men on hormone therapy had new cases of depression, compared with 5.2 % of the others in the study.

During this period, 2.8 % of men on hormone therapy had inpatient psychiatric treatment, compared with 1.9 % of their peers. In addition, 3.4 % received outpatient psychiatric services, versus 2.5 % of the other men.

One limitation of the study is that researchers didn't have data on drug treatments for depression, the authors note in the Journal of Clinical Oncology. It'south also possible that the older age or more advanced tumors of the men receiving hormone therapy might've influenced their odds of depression.

Side effects of hormone therapy such as fatigue, lower libido and sexual performance, and decreased muscle mass may also play a role, said Dr. Sumanta Pal of the City of Hope Comprehensive Cancer Middle in Duarte, California.

"Although it'south within reason to construe that hormone therapy may have a direct impact on the centers in the brain that control mood, it'south necessary to acknowledge that the side effects of hormone therapy may also contribute to the development of depression," Pal, who wasn't involved in the study, said by email.

Because the risk of depression rose with longer treatment, men who consider hormone therapy may wish consider the duration of therapy when deciding whether the benefits are worth the potential side effects, Pal added.

"Prostate cancers that carry a higher risk can either be managed with surgery alone or a combination of radiation with hormone therapy," Pal said. "In the latter scenario, patients with high-risk localized prostate cancer may obtain up to three years of hormone therapy, apparently putting them at substantial risk for depression."

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